Beam and Allis presumed that different combinations of histone modifications to work together in order to form a code, similar to the classic genetic code, in which different combinations of nucleotides to an amino acid. These histone modifications – chemical changes such as phosphorylation, acetylation and methylation – generate a language that is interpreted by the ability to recruit the proteins chromatin chromatin sildenafil vs cialis . ‘But this histone code is much more complicated, as there are more than 100 different histone modifications, and they are in a three-dimensional space, which is working very hard to visualize,’said Beam. ‘We can not say that this mark or this combination of modifications always mean a certain thing. But what I think we can say that more changes can help, the balance of a chromatin state to another, so that the underlying DNA more or less accessible to the protein machinery. ‘.
The ‘histone code ‘was almost a decade ago nearly a decade ago by beam and epigenetics researcher C. David Allis his his postdoctoral advisor at the time. In a review article in the journal Nature, which has been cited more than 3,000 times since released, suggested beam and Allis a model histones histones and their posttranslational modifications in chromatin. Continue reading